Serevent

What is Serevent?

Serevent is a selective long-acting β2-adrenergic receptor agonist (12 hours).

The salmeterol molecule has a long side chain that binds to the outer region of the receptor. Due to this, salmeterol is more effective for the prevention of histamine-induced bronchospasm and causes a longer (at least 12 hours) bronchodilation in comparison with short-acting β2-adrenergic receptor agonists.

Salmeterol inhibits the release in tissues of mast cell mediators such as histamine, leukotrienes and prostaglandin D2. It suppresses the early and late stage of an allergic reaction. After the introduction of a single dose, the suppression of the late stage lasts up to 30 hours, when the bronchodilatory effect is no longer there. A single administration of salmeterol reduces bronchial hyperreactivity.

How to use Serevent Diskus?

• An unused disc contains 60 doses of your medicine.
• The powdery unit doses are precisely measured and hygienically packed. On the counter of the jar, you can read the number of doses remaining.
• The numbers 5 to 0 are marked in red to let you know that only a few doses are available.

How your disk works:

• Moving the lever of your device opens a hole in the mouthpiece from which you can then inhale a dose of powder.
• Open the diskus: To open the diskus, grasp the outer casing with one hand (horizontal, with the can indicator facing up) and place your other thumb on the thumb handle. Push your thumb as far away from you as possible (until it clicks).
• Location: Hold the diskus with the mouthpiece towards you. Slide the lever away from you until you hear a click. Your disc is now ready to be inhaled.
• Inhale: Before inhaling, read the instructions carefully. Keep the disc away from your mouth. Exhale as much as possible.
• Important: Never exhale into your disc. Place the mouthpiece on your lips. Inhale evenly and deeply through the diskus, not through your nose. Take the disc out of your mouth. Hold your breath for 10 seconds or as long as you can. Exhale slowly.

Close: To close the diskus, place your thumb in the thumb handle and push it back as far as possible. When you close the device, it locks into place. The lever automatically returns to its original position. Your disc is now ready for another breath.

Important: Close the diskus when not use it. Do not push the lever of the device unnecessarily, as the dose is released with each “loading motion”. If your doctor has prescribed a 2nd inhalation for you, you must close the diskus and repeat steps 1 through 4.

What is Serevent inhaler used for?

Adults

Bronchial asthma, including the prevention of exercise-induced bronchospasm;

Chronic obstructive pulmonary disease (COPD), including chronic obstructive bronchitis and pulmonary emphysema.

Children over the age of 4

Bronchial asthma, including the prevention of exercise-induced bronchospasm.

What is the active ingredient in this inhaler?

Salmeterol, the active ingredient, inhibits the release in tissues of mast cell mediators such as histamine, leukotrienes and prostaglandin D2. It suppresses the early and late stage of an allergic reaction. After the single dose introduction, suppression of the late stage lasts up to 30 hours, when the bronchodilatory effect is no longer present. A single administration of salmeterol reduces bronchial hyperreactivity.

Salmeterol also increases the frequency of movement of cilia of the ciliated epithelium, improves mucociliary clearance, reduces damage to the epithelium of the respiratory tract caused by Haemophilus influenzae and Pseudomonas aeruginosa. It also has antineutrophilic activity and the ability to reduce mucosal edema by reducing the release of protein through the vascular wall.

What to take if serevent reaction?

Symptoms ща an overdose include tremors, headache, and tachycardia. It is preferably prescribed the introduction of cardioselective beta-blockers. But it should be taken with caution because these drugs can cause bronchospasm.

Is Serevent a preventer?

This inhaler is a long-acting bronchodilator. I means Serevent is not a preventer. Together with this inhaler, a doctor will prescribe a preventer (short-acting drug). In combination, it will bring a great benefit in asthma control and prevention.

Is there a generic for this drug?

Salmeterol is a generic of Serevent. It is prescribed for the same health conditions – asthma and COPD. Salmeterol is the same drug containing the same active ingredient. The only difference lies in the price. The generic analog will cost less in comparison with branded drug.

What effects does this inhaler have on exercise?

Serevent inhaler can be taken in case of exercise-induced asthma. It should be taken 30 minutes before workouts. It will help relieve bronchospasm and enjoy sport activities.

How to get Serevent?

Serevent is intended for use exclusively in the form of inhalation. The drug can be applied through a spacer. To achieve optimal therapeutic effect, the drug should be used regularly. The duration of the treatment course is determined by the doctor.

For adults, bronchial asthma and COPD treatment requires the recommended dose of 2 inhalations (2 x 25 μg salmeterol) 2 times/day.

The maximum dose (with more pronounced airway obstruction in patients with bronchial asthma) is 4 inhalations (4 x 25 μg salmeterol) 2 times/day.

For children over 4 years of age, the recommended dose is 1-2 inhalations (25-50 mcg of salmeterol) 2 times/day.

The maximum daily dose for children and adolescents aged 4 to 18 years is not over 100 mcg of salmeterol (no more than 2 inhalations 2 times/day).

Patients with impaired renal function and elderly patients do not need to change the dose of the drug.

What is the usual dosage of this drug?

Usually, the dosage of this drug is prescribed by a doctor individually. The doctor will assess the overal patient’s state.