Hemangioblastic Derivatives from Human Induced Pluripotent Stem Cells Exhibit Limited Expansion and Early Senescence
Qiang Feng1 , Shi-Jiang Lu1*, Irina Klimanskaya2 , Ignatius Gomes3 , Dohoon Kim4 , Young Chung1 , George R Honig3 , Kwang-Soo Kim1,4, Robert Lanza1,2*
1 Stem Cell and Regenerative Medicine International, 381 Plantation Street, Worcester, MA 01605, USA; 2 Advanced Cell Technology, 381 Plantation Street, Worcester, MA 01605, USA; 3 Department of Pediatrics, University of Illinois at Chicago, 840 South Wood Street, Chicago, IL 60607, USA; 4 Molecular Neurobiology Laboratory, McLean Hospital/Harvard Medical School, and Harvard Stem Cell Institute, 115 Mill Street, Belmont, MA 02478, USA
Keyword: Differentiation | Pluripotent stem cells | Embryonic stem cells | Endothelial differentiation | Hemangioblast | Hematopoietic cells | Proliferation | Reprogramming